The pleiotropic benefits of statins

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August undefined, 2024

WebbThis paper builds on these findings and presents practical guidance for maximising the pleiotropic benefits of this class of medicines in people with T2DM in terms of reducing adverse CVD outcomes. The Improving Diabetes Steering Committee aims to offer evidence-based practical guidance for the use of SGLT2i therapies in people with T2DM … Webb1 aug. 2002 · Because serum cholesterol level is strongly associated with coronary heart disease (), it has been generally assumed that cholesterol reduction by statins is the predominant, if not the only, mechanism underlying their beneficial effects in cardiovascular diseases.However, subgroup analysis of large clinical trials such as the …

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WebbPitavastatin has been shown to have similar pleiotropic effects to other statins, including decreasing platelet activation and improving cardiac and endothelial function. 32 Thus, it … Webb17 okt. 2024 · However, the clinical benefit of statin-induced elevation of HDL-cholesterol is unclear from trial data, ... statins have pleiotropic benefits including prevention of LDL oxidation. View full-text. north korea invented the burrito

Statin - Wikipedia

WebbHowever, it is not clear that the purported effectiveness of statins in neurodegenerative disorders is directly related to cholesterol-lowering effects of these agents; rather, the pleiotropic functions of statins likely play critical roles. Moreover, it is becoming more apparent with… Visualizza altro Webb22 juli 2024 · As a result of their pleiotropic effects statins modulate virtually all known processes of atherosclerosis and have beneficial effects outside the cardiovascular … Webb1 juni 2004 · These non-lipid-lowering (pleiotropic) effects of statin therapy are believed to include antiinflammatory actions, property to reverse endothelial dysfunction by decreasing LDL oxidation and increasing nitric oxide bioavailability. north korea invades south korea 1950

Effects of statin therapy on renal outcomes CLEP

Impact of Previous Stroke on Short-Term Myocardial Reinfarction …

Webb5 jan. 2012 · Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory … Webb18 maj 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis ... Role of statin pleiotropism in acute coronary syndromes and stroke. Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syn... how to say lindsayWebb26 okt. 2024 · Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a … north korea iphone

"WebbPleiotropic effects · Risk factors Abstract Introduction: Autoimmune thyroiditis seems to be associ-ated with increased cardiometabolic risk. Statins, the main-stay of cardiovascular risk reduction and prevention, were found to reduce thyroid antibody titers. The aim of this study was to investigate plasma markers of cardiometabolic risk in " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Pleiotropic Effects of Statins: Lipid Reduction and Beyond

WebbThis narrative review summarizes the evidence regarding the benefits of lipid-lowering drugs in reducing cardiovascular events, the pleiotropic effect of statins, real-world data … Webb15 juni 2007 · Furthermore, at normal doses, statins inhibit cholesterol metabolism by macrophages and may lead to a reduction in macrophage activation and participation in …

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WebbSaeid Ghavami Associate Editor at Elsevier, Frontiers, PLOS, and MDPI publishing group Webb1 dec. 2024 · In addition, the synergistic anti-cancer effects of statins, when combined with other (anti-cancer) drugs, will be discussed in this paper. 2. Pleiotropic properties of statins. “Pleiotropy” originates from the Greek words “pleion” (more) and “tropos” (direction/way), meaning “more than one way”.

Webb6 maj 2016 · These may be predicted as harmful or beneficial effects of the drug. The most wonderful positive pleiotropic effects of statins are anti-inflammatory, anti-proliferative, antithrombotic, improving endothelial dysfunction, and neuroprotective besides many others (Lewington et al. 2007; DuBroff and De Lorgeril 2015 ). WebbThe noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque …

WebbCurrently, new benefits of statins, not dependent on the reduction of LDL cholesterol, have been proposed in the setting of ACS. These effects, which are not dependent on the reduction of LDL cholesterol, are called pleiotropic [Liao, 2005]. Some of the possible effects of statins, which may participate in the benefits that they represent for Webb27 okt. 2016 · Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease. Circulation. 2016 Apr 19;133(16):1574-81. Robinson JG, Ray K. Moving Toward the Next Paradigm for Cardiovascular Prevention. Circulation. 2016 Apr 19;133(16):1533-6.

Webbis important to evaluate the overall benefit of statins in an older population. To this end, our disability-free survival outcome including detailed ascertainment of dementia using well validated measures of cognition, such as those used in the ASPREE trial 35 and advocated by others, 33 will allow us to determine whether statins reduce major ...

WebbPleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, … north korea in warWebbAccumulating evidence have suggested that statins, in addition to LDL-C lowering, exhibited properties of plaque stabilization and endothelial homeostasis; anti … north korea ip rangeWebbEvidence for the pleiotropic effects of statins in heart failure comes largely from retrospective and subgroup analyses of large studies. When statin therapy is compared … how to say linda in hebrewWebbThe noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque … north korea investment stocksWebb6 jan. 2024 · The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol … north korea is known as the land ofWebbBeneficial Cardiovascular Pleiotropic Effects of Statins Jean Davignon, MD Abstract—Pleiotropic effects of a drug are actions other than those for which the agent … how to say lindt chocolateWebb1 feb. 2015 · The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. The concept of lipoproteins as lipid transporters has evolved to encompass functions in coagulation, inflammation, and redox reactions due to their unique protein cargo. north korea invades south map